Heterocyclic amide leukotriene antagonists

Details Heterocyclic amide leukotriene antagonists Heterocyclic amide leukotriene antagonists

C - Chemistry, Metallurgy

07

D

167/208, 260/280

C07D 209/40 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/18 (2006.01) C07D 209/30 (2006.01) C07D 209/88 (2006.01) C07D 231/56 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1273934

A B S T R A C T HETEROCYCLIC AMIDE LEUKOTRIENE ANTAGONISTS The invention provides a series of novel heterocyclic amides of the formula I in which the group A.CRa can be -CRb=CRa-, -CHRb-CHRa- or -N=CRa-, the amidic group Re.L can be Re.X.CO.NH, Re.X.CS.NH or Re.NH.CO attached at position 4, 5 or 6 of the benzenoid moiety, Z is an acid group selected from the group consisting of carboxy, an acylsulphonamide residue of the formula CO.NH.SOnRa and a tetrazolyl residue of the formula II, and the radicals Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, n, X, G1, Q and G2 have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

493372

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