Heterocyclic amides to inhibit tumor metastasis

A - Human Necessities – 61 – K

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167/223

A61K 31/495 (2006.01)

Patent

CA 2004442

4519N ABSTRACT A method of inhibiting tumor metastasis in an animal by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: Image wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a Image J group wherein q, r and t are independently an integer of from 1 to 8 provided that q + r + t is equal to or less 4519N than 10; Y is thio or sulfinyl; Alk is straight or branched chain lower alkylene, and R3 is a heterocyclic amine represented by the formula: Image wherein R4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, or substituted benzyl; p is 0 to 2; or a pharmaceutically acceptable salt thereof.

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