C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/4427 (2006.01) A61P 35/00 (2006.01) C07D 213/40 (2006.01) C07D 213/73 (2006.01) C07D 233/61 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 473/00 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2696767
The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2 or R3 is (Z).
L'invention concerne des composés d'amides hétérocycliques qui sont utiles pour inhiber la voie de signalisation Hedgehog, et l'utilisation de ces composés pour traiter une maladie ou un état pathologique causé(e) uniquement ou en partie par l'inhibition de la voie Hedgehog. L'invention concerne aussi des procédés de fabrication de ces composés, des compositions pharmaceutiques comprenant ceux-ci et l'utilisation de ces composés pour fabriquer des médicaments destinés à traiter ces maladies ou états pathologiques chez un sujet. Formule (IA), à condition que R2 ou R3 représente (Z).
Dakin Leslie
Fauber Benjamin
Hird Alexander
Janetka James
Russell Daniel John
Astrazeneca Ab
Fetherstonhaugh & Co.
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