Heterocyclic amines having central nervous system activity

Details Heterocyclic amines having central nervous system activity Heterocyclic amines having central nervous system activity

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 215/40 (2006.01) C07D 455/04 (2006.01) C07D 498/06 (2006.01) C07D 513/06 (2006.01)

Patent

CA 2051697

Tricyclic nitrogen containing compounds, having central nervous system activity of structural formula (I) and pharmaceuti- cally acceptable salts thereof, wherein R1, R2, and R3 are independently hydrogen, C1-6 alkyl, alkenyl, or alkynyl, C3-10 cyc- loalkyl, or R1 and R2 are joined to form a C3-7 cyclic amine which can contain additional heteroatoms, X is hydrogen, C1-6 alkyl, halogen, hydroxy, alkoxy, cyano carboalkoxyl, or carboalkoxyl; A is SO2, N, CH, CH2, CHCH3, C=O, C=S, C-SCH3, C=NH, C-NH2, C-NHCH3, C-NHCOOCH3, or C-NHCN; B is CH2,CH, C=O, N, NH or N-CH3; n is 0 or 1; and D is CH, CH2, C = O, O, N, NH or N-CH3. These new compounds are suitable for treating schizophrenia, Par- kinson's disease, anxiety, depression or as compounds for lowering blood pressure in animal or human hosts.

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