Heterocyclic amines having central nervous system activity

Details Heterocyclic amines having central nervous system activity Heterocyclic amines having central nervous system activity

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2166700

Tricyclic nitrogen containing compounds, having anxiolytic and anti-depressant activity and central nervous system activity of structural formula (T) and pharmaceutically acceptable salts thereof wherein R1 and R2 are independently hydrogen, C1-6 alkyl or R1 and R2 are joined to form pyrrolidine, pireridine, morpholine or imidazole. X is OCH3, SO2R3, SO2CF3 or CN where R3 is C1-6 alkyl or an aryl; and Y is hydrogen, Cl, Br, F, CN, CONR1R2, CF3, OCH3, SO2NR1R2. These new compounds are suitable for treating anxiolytic disorder, schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure or treating migraine headaches in patients in need of such treatment.

Composés contenant de l'azote tricyclique, présentant une activité anxiolytique et anti-dépressive ainsi qu'une activité sur le système nerveux central, de formule structurelle (I), et sels de ces composés utilisables dans des applications pharmaceutiques. Dans cette formule, R1 et R2 repésentent indépendament hydrogène, alkyle C1-6 ou R1 et R2 sont liés pour former pyrrolydine, pipéridine, morpholine ou imidazole. X représente OCH3, SO2R3, SO2CF3 ou CN dans lesquels R3 représente alkyle C1-6 ou un aryle; Y représente hydrogène, Cl, Br, F, CN, CONR1R2, CF3, OCH3, SO2NR1R2. Ces nouveaux composés sont adaptés au traitement de troubles anxiolytiques, de la schizophrénie, de la maladie de Parkinson, de l'anxiété, de la dépression, ou peuvent être utilisés pour diminuer la tension artérielle ou pour le traitement des migraines chez les patients nécessitant ce type de traitement.

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