Heterocyclic anti-migraine agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/10 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2549401

The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (~CGRP-receptor~), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

La présente invention a trait à des composés de formule (I) en tant qu'antagonistes des récepteurs peptidiques associés au gène calcitonine (récepteur CGRP), à des composition pharmaceutiques les contenant, à leurs procédés d'identification, à des procédés de traitement les mettant en oeuvre et à leur utilisation en thérapie pour le traitement de vasodilatation neurogène, d'inflammation neurogène, de la migraine et autres maux de tête, de la brûlure thermique, du choc circulatoire, des bouffées de chaleur associées à la ménopause, de maladies inflammatoires des voies aériennes, telles que l'asthme et la broncho-pneumopathie chronique obstructive (BPCO), et d'autres conditions dont le traitement peut être effectué par l'antagonisme des récepteurs peptidiques associés au gène calcitonine (récepteurs CGRP).

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