Heterocyclic antiviral compounds

Details Heterocyclic antiviral compounds Heterocyclic antiviral compounds

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/4709 (2006.01) A61K 31/4741 (2006.01) A61P 31/00 (2006.01) C07D 405/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2752443

Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, R a, R b, R c, R d, X, X1, X2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

L'invention porte sur des composés représentés par la formule A-R, dans laquelle A représente un hétéroaryle et R représente Ia, Ib ou Ic et dans laquelle A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 et n sont tels que définis dans la description. Lesdits composés sont des inhibiteurs de la polymérase NS5b du virus de l'hépatite C. L'invention porte également sur des compositions et des procédés de traitement d'une infection à VHC et d'inhibition de la réplication du VHC.

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