Heterocyclic antiviral compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/04 (2006.01) A61K 31/541 (2006.01) A61P 31/14 (2006.01) C07D 221/00 (2006.01) C07D 333/00 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2577528

Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed are processes for making the compounds and synthetic intermediates used in the process (I).

La présente invention a pour objet des inhibiteurs de la polymérase du virus de l~Hépatite C. Lesdits inhibiteurs sont des composés de formule I où A, m et R1 sont tels que définis dans la présente invention. La présente invention décrit également des préparations et des méthodes permettant de traiter les maladies provoquées par le VHC et d'inhiber la réplication dudit virus. La présente invention a également pour objet des procédés de synthèse desdits composés, ainsi que les intermédiaires de synthèse utilisés dans le procédé (I).

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