C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61K 31/415 (2006.01) A61K 31/416 (2006.01) A61K 31/4196 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61K 31/4245 (2006.01) A61K 31/425 (2006.01) A61K 31/428 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/5025 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K
Patent
CA 2496842
Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula (I) wherein R1, R1', R2, R3, R4, Xa, Y, Z, and n are as described herein. The compounds provided herein are useful in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
L'invention concerne de nouveaux composés aromatiques hétérocycliques utiles dans la stimulation de la production ou de la libération endogène d'une hormone de croissance. Ces composés présentent la structure générale de formule (I), dans laquelle R¿1?, R¿1? , R¿2?, R¿3?, R¿4?, Xa, Y, Z, et n sont tels que décrits dans la description. Lesdits composés sont utiles dans le traitement de l'obésité, de l'ostéoporose (améliorant la densité osseuse) et dans l'amélioration de la masse musculaire et de la force musculaire.
Ewing William R.
Li James J.
Li Jun
Sulsky Richard B.
Tino Joseph A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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