C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/14 (2006.01) A61K 31/513 (2006.01) A61P 25/28 (2006.01) C07D 239/22 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 495/10 (2006.01)
Patent
CA 2653650
Disclosed are compounds of formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
La présente invention concerne des composés répondant à la formule (I) ou un stéréoisomère, un tautomère, ou un sel ou un solvate pharmaceutiquement acceptable de ces composés, U, W, X, R1, R2, R6, R7, R30 et R31 étant tels que décrits précédemment dans la description. L'invention concerne également le procédé d'inhibition de l'aspartyl protéase, et en particulier, les procédés de traitement de maladies cardiovasculaires, cognitives et neurodégénératives. L'invention concerne également des procédés de traitement de maladies cognitives ou neurodégénératives par les composés répondant à la formule I combinés à un inhibiteur de cholinestérase ou à un agoniste muscarinique m1 ou à un antagoniste muscarinique m2.
Cumming Jared
Huang Ying
Iserloh Ulrich
Liu Xiaoxiang
Mazzola Robert D.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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