C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/88 (2006.01) A61K 31/395 (2006.01) A61K 31/4168 (2006.01) A61K 31/506 (2006.01) C07D 239/22 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/08 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2548388
Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula (I) in combination with a cholinesterase inhibitor or a muscarinic antagonist.
L'invention concerne des composés de formule (I) ou un stéréoisomère, tautomère, sel pharmaceutiquement acceptable ou solvate de ceux-ci. L'invention également encore un procédé permettant d'inhiber la protéase aspartyle, et plus spécifiquement des procédés permettant de traiter des maladies cardio-vasculaires, des maladies cognitives et neurodégénératives, ainsi que des procédés permettant d'inhiber le virus de l'immunodéficience humaine, des plasmepins, la cathepsine D et des enzymes protozoaires. L'invention concerne enfin des procédés permettant de traiter des maladies cognitives ou neurodégénératives au moyen de composés de formule (I) combinés à un inhibiteur de cholinestérase ou un antagoniste muscarinique.
Babu Suresh D.
Caldwell John
Cumming Jared
Greenlee William J.
Guo Tao
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Pharmacopeia Inc.
Pharmacopeia Drug Discovery Inc.
Schering Corporation
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