C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/68 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) C07D 215/48 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2177146
The present invention relates to heterocyclic benzenesulfonylimine derivatives and their use inhibitors of Interleukin-1(IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheumatoid arthritis, multiple sclerosis. diabetes mellitus, atherosclerosis, septic shock and pulmonary fibrosis.
La présente invention se rapporte à des dérivés de benzènesulfonylimine hétérocycliques ainsi qu'à l'utilisation de ceux-ci en tant qu'inhibiteurs de l'action de l'Interleukine-1 (IL-1). De tels inhibiteurs sont utiles dans le traitement de divers états maladifs tels ceux décrits ici, notamment l'arthrite rhumatoïde, la sclérose en plaques, le diabète sucré, l'athérosclérose, le choc septique et la fibrose pulmonaire.
Harrison Boyd L.
Ku George
Stemerick David M.
Aventisub II Inc.
Osler Hoskin & Harcourt Llp
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