Heterocyclic bisphosphonic acid derivatives

Details Heterocyclic bisphosphonic acid derivatives Heterocyclic bisphosphonic acid derivatives

C - Chemistry, Metallurgy

07

F

167/231, 167/233

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1332058

Abstract of the disclosure A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): Image (I) in which, Image means one of following (A) and (B): Image (A) wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, Image (B) wherein R6 and R7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group, R1 represents a hydrogen atom or a hydroxyl group, R2, R3, R4 and R5 may be the same or different, each represents a hydrogen atom or a lower alkyl group, "n" is 0 or 1, provided that "n" is 1 when the ring Image means (A), and "R1" is a hydroxyl group when the ring Image means (B), or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient. - 27 -

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