C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 5/02 (2006.01) C07D 207/10 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01)
Patent
CA 2602772
Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12) cy-cloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X to-gether with an adjacent ring carbon and Z form a fused cyclopropyl; and op-tionally, one of the bonds in the ring containing X is a double bond; and Cr i R ii, R1, R1, R3, R4 and R5 arc as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
Betancort Juan M.
Campbell David A.
Hu Yi
Li Bei
Ma Lifu
Goudreau Gage Dubuc
Phenomix Corporation
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