C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/255, 260/308
C07D 207/327 (2006.01) C07D 207/404 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/74 (2006.01) C07D 237/14 (2006.01) C07D 239/36 (2006.01) C07D 249/12 (2006.01) C07D 253/07 (2006.01) C07D 257/04 (2006.01) C07D 277/24 (2006.01) C07D 277/30 (2006.01)
Patent
CA 2036192
ABSTRACT Heterocyclic acids and esters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I, II and VIII are disclosed. HET1-(CH2)nCO2R (I) Image (II) Image (VIII) Formula I compounds are those wherein n is 6-9, R is hydrogen, lower alkyl or an alkali metal ion, and HET1 is heterocyclic radical selected from the group consisting of 3,4-diphenyl-1H-pyrrol-1-yl, 1,6-dihydro-6-oxo-3,4-diphenyl- 1-pyridazinyl, 2,3-dihydro-3-oxo-5,6-diphenyl-1,2,4-triazin- 2-yl, 1-oxo-4,5 diphenyl-2H-pyrimidin-1-yl, 2,5-dioxo-3,4- diphenylimidazolidin-1-yl, 5-(diphenylmethyl)-2H-tetrazol- 2-yl, 4,5-diphenyl-2-thiazoyl, 4,5-diphenyl-1H-imidazol- 2-yl, and 1,5-diphenyl-1H pyrazol-3-yl. Formula II compounds are those wherein R1 is hydrogen, lower alkyl or an alkali metal ion, and the radical -OCH2CO2R is attached in the 3 or 4 ring position; and HET2 is a heterocyclic radical selected from the group consisting of 4,5-diphenyl-2-thiazoyl, 4,5-diphenyl-1H- imidazol-2-yl, 3,4-diphenyl-1H-pyrazol-1-yl, 4,5-diphenyl- 1H-pyrazol-1-yl, 1,5-diphenyl-1H-pyrazol-3-yl, 1,6-dihydro- 6-oxo-3,4-diphenyl-1-pyridazinyl, 2,3-dihydro-3-oxo-5,6- diphenylmethyl-1,2,3-triazin-2-yl, and 5-(diphenylmethyl)- 2H-tetrazol-2-yl. Formula VIII compounds are those wherein R1 is hydrogen, lower alkyl or an alkali metal ion, and the radical -OCH2CO2R is attached in the 3 or 4 ring position.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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