Heterocyclic cgrp antagonists for the treatment of migraine

Details Heterocyclic cgrp antagonists for the treatment of migraine Heterocyclic cgrp antagonists for the treatment of migraine

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2562039

The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (~CGRP-receptor~), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

La présente invention concerne des composés représentés par la formule (I) agissant en tant qu'antagonistes des récepteurs peptidiques associés au gène de la calcitonine ( récepteur CGRP ), des compositions pharmaceutiques renfermant lesdits composés, des méthodes de traitement utilisant ces antagonistes et leur utilisation thérapeutique dans le traitement des troubles et pathologies suivantes : vasodilatation neurogène, inflammation neurogène, migraine et autres céphalées, brûlures thermiques, choc circulatoire, bouffées vasomotrices associées à la ménopause, troubles inflammatoires des voies respiratoires tels que l'asthme et la broncho-pneumopathie obstructive chronique, et autres pathologies dont le traitement peut faire appel à l'antagonisme des récepteurs CGRP.

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