Heterocyclic compound

Details Heterocyclic compound Heterocyclic compound

C - Chemistry, Metallurgy

07

D

C07D 451/12 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2184366

Endo-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): Image or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activat- ing gastrointestinal motor functions and thus is effec- tive for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postopera- tive gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.

La présente invention concerne un endo-(8-méthyl-8-azabicyclo(3.2.1)oct-3-yl) 1-isopropyl-2-1H)-quinilone-3-carboxylate représenté par la formule ou l'un ses sels obtenus par addition acide, ce composé agissant sur les récepteurs de la sérotonine 4 et faisant preuve d'un effet de stimulation des récepteurs semblables à la sérotonine. Ce composé, capable donc d'activer la motilité des voies digestives, fait preuve d'efficacité pour l'amélioration des symptômes digestifs accompagnant notamment la gastrite chronique et le syndrome post-gastrectomique tels que la pyrosis, l'anorexie, l'épigastralgie, le météorisme abdominal, et pour le traitement de l'oesophagite peptique, de l'iléus paralytique et de la constipation.

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