Heterocyclic compound

Details Heterocyclic compound Heterocyclic compound

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/10 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 17/16 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 21/00 (2006.01) A61P 21/04 (

Patent

CA 2605594

Disclosed is a novel low toxic compound having an excellent immunosuppressive action or a pharmacologically acceptable salt thereof. Specifically disclosed is a compound represented by the general formula (I) below, a pharmacologically acceptable salt thereof or a pharmacologically acceptable prodrug thereof. (I) (In the formula, A represents a carboxyl group or the like; B represents a hydrogen atom or the like; V represents a single bond, a methylene group or the like; n represents an integer of 0-2; W represents a 5- to 7-membered heterocyclic group or the like; and Z represents a group or the like selected from a substituent group A consisting of halogen atoms, C1-C6 alkyl groups, C3-C7 cycloalkyl groups and the like.)

L'invention concerne un nouveau composé faiblement toxique, ayant une excellente action immunosuppressive, ou un de ses sels pharmaceutiquement acceptables. L'invention concerne notamment un composé représenté par la formule générale (I) ci-dessous, ou un de ses sels ou promédicaments pharmaceutiquement acceptables. (I) (Dans la formule, A représente un groupe carboxyle ou similaires ; B représente un atome d'hydrogène ou similaires ; V représente une liaison simple, un groupe méthylène ou similaires ; n représente un entier entre 0 et 2 ; W représente un groupe hétérocyclique à 5 à 7 chaînons ou similaires ; et Z représente un groupe ou similaires choisi parmi ou groupe substituant A consistant en des atomes d'halogène, des groupes alkyle en C1-C6, des groupes cycloalkyle en C3-C7 et similaires).

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