C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2297326
Heterocyclic compounds in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which are represented by the Formula I or phermaceutically acceptable acid addition salts thereof: (see formula I) wherein X and Y respectively represent nitrogen atom or one of them represents nitrogen atom and the other represents C- R7 wherein R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino, piperidino, piperazinyl, thiomorpholino, benzimidazolyl, cyano or the like.
L'invention concerne des composés hétérocycliques de la formule générale (I) contenant un noyau s-triazine ou pyrimidine substitué par benzimidazole et morpholine, ou des sels d'addition acides pharmaceutiquement acceptables desdits composés. Dans ladite formule, X et Y sont l'un et l'autre un atome d'azote, ou soit X soit Y est un atome d'azote et l'autre élément est C-R7 (R7 étant un atome d'hydrogène ou un atome d'halogène); R1, R2, R4, R5 et R6 sont chacun un atome d'hydrogène ou alkyle C1-C6; et R3 est morpholino, piperidino, piperazinyle, thiomorpholino, benzimidazolyle, cyano ou un élément similaire.
Inaba Masahiro
Kawashima Seiichiro
Matsuno Toshiyuki
Watanabe Tetsuo
Yaguchi Shinichi
Fetherstonhaugh & Co.
Zenyaku Kogyo Kabushiki Kaisha
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