C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/4418 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 239/34 (2006.01) C07D 239/38 (2006.01) C07D 239/42 (2006.01) C07D 241/12 (2006.01) C07D 241/18 (2006.01) C0
Patent
CA 2445344
The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (see formula 1) (R1 and R2 are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5 represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3 and R4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N--(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.
L'invention concerne des composés utiles en tant qu'agonistes du récepteur PGI¿2? et des compositions pharmaceutiques, en particulier des compositions pharmaceutiques contenant, en tant que principe actif, des composés représentés par la formule générale (I) ou leurs sels pharmaceutiquement acceptables, formule dans laquelle R?1¿ et R?2¿ représentent chacun indépendamment aryle facultativement substitué, Y représente N, CH ou analogue ; Z représente N, CH ou analogue ; A représente NH, NR?5¿, O, S, éthylène ou analogue ; R?5¿ représente alkyle ou analogue ; D représente alkylène ou alcénylène ; E représente phénylène ou une liaison simple ; G représente O, S, CH?2¿ ou analogue ; R?3¿ et R?4¿ représentent chacun indépendamment hydrogène ou alkyle ; et Q représente carboxyle, alcoxycarbonyle, tétrazolyle, carboamoyle, N-(alkylsulfonyl)carbamoyle, ou analogue.
Asaki Tetsuo
Hamamoto Taisuke
Kuwano Keiichi
Fetherstonhaugh & Co.
Nippon Shinyaku Co. Ltd.
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