C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/12 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2117179
2117179 9307156 PCTABS00021 The present invention relates to novel naphthoquinones of formula (I) wherein R3 is a C1-35 non-aromatic hydrocarbon residue optionally substituted by one or more substituents selected from halo, C1-6 alkoxy, hydroxy, phenyl, phenyl-C1-6alkoxy and phenyl-C1-6alkyl, each such phenyl group or mainly being optionally substituted by one or more groups selected from C1-6alkoxy, C1-6alkyl, C1-6alkoxy-C1-6alkyl, hydroxy, halogen, halo-C1-6alkyl, amine and mono- or di-C1-4alkyl-amino; and either the dotted line represents a double bond between the 2 and 3 positions of the naphthyl ring, R1 and R4 each represents =O, and R2 represents a phosphate group (.alpha.) wherein R5 and R6 which may be the same or different, each represent a hydrogen atom or a C1-6alkyl group; or the dotted line represents double bonds between the 1,2 and 3,4 positions of the naphthyl ring, and R1, R2 and R4 each represent a phosphate group: -OP(O)(OR5)(OR6) (wherein R5 and R6 are as hereinbefore described) and physiologically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of parasitic infections.
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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