Heterocyclic compounds

Details Heterocyclic compounds Heterocyclic compounds

C - Chemistry, Metallurgy

07

D

260/328, 260/356

C07D 311/96 (2006.01) C07D 221/20 (2006.01) C07D 311/22 (2006.01) C07D 335/06 (2006.01) C07D 487/04 (2006.01) C07D 495/10 (2006.01)

Patent

CA 2021926

- 98 - Abstract of the disclosure: A novel heterocyclic compound capable of lowering the uric acid levels in plasma and urine having the formula (I): Image (I) wherein R1 and R2 are independently hydrogen, lower alkyl, phenyl or substituted phenyl, or R1 and R2 may form a four- to eight-membered carbon ring together with the carbon atom to which they are attached; R3 is hydrogen or lower alkyl; R4 is one or two radicals selected from a group consisting of hydrogen, halogen, nitro, lower alkyl, phenyl, substituted phenyl, -OR5 and -SO2NR6R6'; R5 is hydrogen, lower alkyl, phenyl-substituted lower alkyl, carboxymethyl or ester thereof, hydroxyethyl or ether thereof, or allyl; R6 and R6' are independently hydrogen or lower alkyl; R7 is hydrogen or a pharmaceutically active ester-forming group; A is a straight or branched hydrocarbon radical having one to five carbon atoms; B is halogen, oxygen, or dithiolane; Y is oxygen, sulfur nitrogen or substituted nitrogen; Z is oxygen, nitrogen or substituted nitrogen; dotted line represents the presence or absence of a single bond.

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