Heterocyclic compounds

Details Heterocyclic compounds Heterocyclic compounds

C - Chemistry, Metallurgy

07

D

167/208, 260/251

C07D 233/90 (2006.01) A61K 31/41 (2006.01) C07D 249/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1304741

A B S T R A C T A heterocyclic compound of the formula I, as shown hereafter in these claims in which n is 0 or 1; A is a 1-4C alkylene radical which may optionally bear one or more 1-4C alkyl substituents; R1 and R2, which may be the same or different, are each a hydrogen or halogen atom; an amino, carbamoyl, cyano, hydroxy, nitro or sulphamoyl radical, a 1-6C alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylamino, alkylcarbamoyl or alkylsulphamoyl radical, a di(1-6C alkyl)-amino, di(1-6C alkyl)carbamoyl or di(1-6C alkyl)sulphamoyl radical, or a 2-7C alkoxycarbonyl radical m is an integer of 1 to 5, R3 is a hydrogen or halogen atom or a 1-6C alkyl or halogenoalkyl radical; and R4 is a 5-membered aromatic ring heterocyclyl radical containing 2 or 3 nitrogen atoms, or a 6-membered aromatic ring heterocyclyl radical containing 1 or 2 nitrogen atoms, which heterocyclyl radical may bear a 1-6C alkyl substituent; and for those compounds which contain a basic nitrogen atom, the pharmaceuticaIly acceptable acid addition salts thereof together with processes of manufacture and pharmaceutical and veterinary compositions thereof.

560397

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