Heterocyclic compounds and expansion agents for...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61K 31/4436 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 38/00 (2006.01) A61K 38/22 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 7/06 (2006.01) A61P 9/10 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2760655

Disclosed is an amplifier for hematopoietic stem cells and/or hematopoietic progenitor cells which is useful for treating various diseases and for improving the efficiency of transferring a gene into hematopoietic stem cells in gene therapy. An amplifier for hematopoietic stem cells and/or hematopoietic progenitor cells and a drug, which contain, as the active ingredient, a compound represented by formula (I) [wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are each as defined in the description], a tautomer of said compound, or a prodrug, a pharmaceutically acceptable salt or a solvate of the same, characterized by being capable of amplifying hematopoietic stem cells and/or hematopoietic progenitor cells.

La présente invention a pour objet un amplificateur pour cellules souches hématopoïétiques et/ou cellules progénitrices hématopoïétiques qui est utile pour le traitement de différentes maladies et pour l'amélioration de l'efficacité du transfert d'un gène dans des cellules souches hématopoïétiques en thérapie génique. La présente invention a pour objet un amplificateur pour cellules souches hématopoïétiques et/ou cellules progénitrices hématopoïétiques et un médicament, qui contiennent, en tant qu'ingrédient actif, un composé représenté par la formule (I) [X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 et R7 étant chacun tels que définis dans la description], un tautomère dudit composé, ou un promédicament, un sel pharmaceutiquement acceptable ou un solvate de celui-ci, caractérisés en ce qu'ils sont capables d'amplifier des cellules souches hématopoïétiques et/ou des cellules progénitrices hématopoïétiques.

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