Heterocyclic compounds and methods of use

Details Heterocyclic compounds and methods of use Heterocyclic compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61P 1/04 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 11/00 (2006.01) A61P 25/28 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 207/48 (2006.01) C07D 209/42 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2463154

Compounds of the formula (I) provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X. Preferred are the compounds of the invention which are dual agonists of PPARa and PPARy receptors.

Composés représentés par la formule (I) constituant des agents pharmacologiques agonistes puissants des récepteurs activés par le proliférateur de péroxisome (PPAR). Ces composés sont, de ce fait, utiles pour traiter des états dans lesquels l'activité du récepteur PPAR joue un rôle chez les mammifères. Ces états consistent en dyslipidémie, hyperlipidémie, hypercholesterolémie, athérosclérose, hypertriglycéridémie, insuffisance cardiaque, infarctus du myocarde, maladies cardio-vasculaires, maladies vasculaires, hypertension, obésité, inflammation, arthrite, cancer, maladie d'Alzheimer, troubles de l'épiderme, maladies respiratoires, troubles ophtalmiques, maladies intestinales inflammatoires, colites ulcératives et maladie de Crohn. Ces composés sont particulièrement utiles chez les mammifères en tant qu'agents hypoglycémiques servant à traiter et à prévenir des états impliquant une défaillance de la tolérance au glucose, l'hyperglycémie et la résistance à l'insuline, tels que des diabètes de type 1 et de type 2, et le syndrome X. Les composés préférés consistent en des doubles agonistes, des récepteurs PPAR.alpha. et PPAR.gamma..

Affiliated with

Also associated with

Rating

Heterocyclic compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1952633