Heterocyclic compounds and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/14 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2518909

The invention relates to compounds of the formulae (I) to (III) wherein the substituents are as defined in the specification. These compounds have kinase inhibitory activity, such as VEGFR/KDR inhibitory activity. Accordingly, the compounds of the formulae (I) to (III) would be useful in the prevention and treatment of angiogenesis related disorders, ophthalmological conditions, proliferative diseases, inflammatory diseases, and other pathological conditions as described in the specification.

La présente invention concerne des composés représentés par les formules (I) à (III) dans lesquelles les substituants sont tels que définis dans la description. Ces composés présentent une action inhibitrice sur la kinase, telle qu'une action inhibitrice sur VEGFR/KDR. Les composés représentés par les formules (I) à (III) sont ainsi utilisés dans la prévention et le traitement de troubles associés à l'angiogenèse, de troubles ophtalmologiques, de maladies prolifératives, de maladies inflammatoires et autres états pathologiques décrits dans la description.

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