Heterocyclic compounds and methods of use

Details Heterocyclic compounds and methods of use Heterocyclic compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4725 (2006.01) A61P 35/00 (2006.01) C07D 455/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2747170

In one aspect, the present invention provides for a com-pound of Formula I; in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compo- sitions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-ex- pression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-X L proteins.

Selon un aspect, la présente invention concerne un composé de formule I où les variables X1a, X1b, X1c, X1d, Q, A, R1, B, L, E et les indices m et n sont tels que décrits ici. Selon un autre aspect, la présente invention concerne des compositions pharmaceutiques comprenant des composés de formule I, ainsi que des procédés d'utilisation desdits composés de formule I en vue du traitement de maladies et d'affections (par exemple le cancer, la thrombocythémie, etc.), caractérisées par l'expression ou la surexpression de protéines anti-apoptotiques Bcl-2, par exemple des protéines anti-apoptotiques Bcl-xL.

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