Heterocyclic compounds and their preparation and use

Details Heterocyclic compounds and their preparation and use Heterocyclic compounds and their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2105675

2105675 9215591 PCTABS00016 Imidazotriazoloquinazoline compounds having general formula (I), wherein A together with the .alpha.-marked carbon atom and the .beta.-marked nitrogen atom is one of the groups (a) or (b); R1 is (c), (d), (e), (f), cyano or CO2R5, wherein R5 is H, alkyl, cycloalkyl, trifluoromethyl or alkoxymethyl; and R2, R3 and R4 independently are H, hydroxy, halogen, CN, alkyl, alkenyl, alkynyl, trifluoromethyl, alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted, a cyclic amino group, or NR6R7, wherein R6 and R7 independently are H or alkyl. The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, or in improving the cognitive function of the brain of mammals, or as benzodiazepine antagonists.

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