C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/70 (2006.01) A61K 31/381 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2643012
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R1, R2, R3, R4, Y, m, n and q are as defined herein. R1 is in particular amidino. The invention further provides particular benzothiophene compounds. Compounds of the invention may be useful as inhibitors of Factor IXa and in the therapy of cardiovascular conditions and diseases, e.g. thrombosis.
La présente invention concerne des composés de formule (I) : le cycle A, le cycle B, R1, R2, R3, R4, Y, m, n et q étant tels que définis dans le présent document. R1 est plus particulièrement amidino. La présente invention concerne également des composés particuliers de benzothiophène. Les composés de l'invention peuvent être utiles en tant qu'inhibiteurs du facteur IXa ainsi que dans le traitement de troubles et maladies cardiovasculaires, p. ex. la thrombose.
Beck Richard
Blench Toby Jonathan
Dickinson Roger Peter
Marlin Frederic
Wang Shouming
Ridout & Maybee Llp
Trigen Limited
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