C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4427 (2006.01) A61K 31/4725 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2672903
Selected compounds of formula (I) are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
L'invention concerne des composés sélectionnés de formule (I) qui sont efficaces pour la prophylaxie et le traitement de maladies, telles que des maladies à médiation par VEGF. L'invention englobe de nouveaux composés, analogues, promédicaments et sels acceptables du point de vue pharmaceutique de ceux-ci, les compositions pharmaceutiques et les procédés pour la prophylaxie et le traitement d'affections et autres maladies ou états y compris le cancer et autres maladies similaires. La présente invention porte également sur des procédés de fabrication de tels composés ainsi que sur des intermédiaires utiles dans de tels procédés.
Cheng Yuan
Choquette Deborah
Harmange Jean-Christophe
Tasker Andrew
Amgen Inc.
Gowling Lafleur Henderson Llp
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