Heterocyclic compounds and their uses

Details Heterocyclic compounds and their uses Heterocyclic compounds and their uses

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2680783

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

L'invention concerne des hétéroaryles bicycliques substitués et des compositions les renfermant, destinés à traiter les inflammations générales, l'arthrite, les maladies rhumatismales, l'arthrose, les troubles entériques inflammatoires, les troubles oculaires inflammatoires, les troubles inflammatoires ou instables de la vessie, le psoriasis, les affections cutanées à composantes inflammatoires, les maladies inflammatoires chroniques, notamment mais non exclusivement les maladies auto-immunes telles que le lupus érythémateux systémique (SLE), myestenia gravis, l'arthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaque, syndrome de Sjoegren et l'anémie hémolytique auto-immune, les affections allergiques comprenant toutes formes d'hypersensibilité. L'invention concerne également des méthodes de traitement des cancers qui sont médiés par, dépendants de ou associés à l'activité p110, y compris mais non seulement les leucémies, telles que la leucémie myéloïde aiguë (AML), le syndrome myélo-dysplastique (MDS), les maladies myélo-prolifératives (MPD), la leucémie myéloïde chronique (CML), la leucémie lymphoblastique aiguë à lymphocytes T (T-ALL), la leucémie lymphoblastique aiguë à lymphocytes B (B-ALL), le lymphome non Hodgkinien (NHL), le lymphome à lymphocytes B et les tumeurs solides, telles que le cancer du sein.

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