Heterocyclic compounds and their uses

Details Heterocyclic compounds and their uses Heterocyclic compounds and their uses

C - Chemistry, Metallurgy

07

D

C07D 473/30 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2681136

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on, or associated with p110 activity, including but not restricted to leukemias, such as acute myeloid leukaemia (AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.

La présente invention concerne des hétéroaryles bicycliques substitués et des compositions les intégrant. Ils permettent de traiter les inflammations générales, l'arthrite, les maladies rhumatismales, l'arthrose, les troubles inflammatoires intestinaux, les troubles inflammatoires ou instables de la vessie, le psoriasis, les désagréments cutanés à composantes inflammatoires, les états inflammatoires chroniques, y-compris, mais de façon non limitative, les maladies auto-immunes telles que le lupus érythémateux systémique (SLE), la myasthénie grave, la polyarthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjögren et l'anémie hémolytique auto-immune, et les états allergiques, y-compris toutes les formes d'hypersensibilité. L'invention concerne étalement des traitements contre des cancers pour lesquels existe un lien de médiation, de dépendance ou d'association avec l'activité p110, y-compris, mais de façon non limitative, des leucémies telles que la leucémie myéloïde aiguë (AML), le syndrome myélodysplasique (MDS), le syndrome myéloprolifératif (MDP), la leucémie myéloïde chronique (CML), la leucémie lymphoblastique aiguë à lymphocytes T (T-ALL), la leucémie lymphoblastique aiguë à lymphocytes B (B-ALL), le lymphome non-hodgkiniens (NHL), le lymphome à lymphocytes B et les tumeurs solides telles que le cancer du sein.

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