C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2693162
Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed. Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
La présente invention concerne de nouveaux composés présentant un système cyclique hétéroaromatique fusionné bicyclique substitué par un cycle hétéroaryle à cinq chaînons. Les composés inhibent la croissance d'une variété de types de cellules cancéreuses, et sont ainsi utiles pour le traitement du cancer. L'efficacité de ces composés est démontrée avec un système permettant de surveiller la croissance/migration cellulaire, qui montre que ce sont de puissants inhibiteurs de la croissance et/ou de la migration des cellules cancéreuses. De plus, il a été démontré que les composés de l'invention arrêtent la croissance des tumeurs in vivo, et réduisent la taille des tumeurs in vivo. La présente invention décrit des compositions comprenant ces composés, et des procédés d'utilisation de ces composés et compositions pour le traitement de cancers.
Abassi Yama
An Haoyun
Wang Xiaobo
Xi Biao
Xu Xiao
Acea Biosciences Inc.
Fetherstonhaugh & Co.
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