Heterocyclic compounds as antagonists of excitatory amino...

Details Heterocyclic compounds as antagonists of excitatory amino... Heterocyclic compounds as antagonists of excitatory amino...

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/59 (2006.01) C07F 9/6509 (2006.01)

Patent

CA 2095224

2095224 9208724 PCTABS00013 Compounds of formula (I), in which X is an imino, a methylene group, a benzylidine, an 1,1-allylidine, a 1,1-alkylidene group containing from two to seven carbons, or is a group D-E in which D, being part of the ring, is nitrogen and E is a straight or branched lower alkyl or acyl each containing one to seven carbons, an aroyl, a substituted or non-substituted allyl, benzyl or propargyl group; Y is a hydroxyl- or amino-bearing carbon or is a carbonyl group; Z is a group consisting of one to four methylene groups or is a 1,3-allylidene or 1,3-propargylidene group; W is a group P(O)(OR1)(OR2) wherein R1 and R2 is each independently hydrogen, C1-C2 alkyl, acyloxymetyl or -etyl; n, when X does not contain nitrogen in the ring, is 1 or 2, or, when X contains nitrogen, is 2; for use as analgetics, anticonvulsants and antiischemic agents, as well as methods for their preparation, their pharmaceutical preparations and their use.

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