C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2667962
A compound of Formula Ia or Ib in free or salt or solvate form, where R1, R2, R3, R4, R5 R20, R24, R25, X, Y and Z have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. These compounds are also useful for treating diseases mediated by the Pi3k receptor, the JAK-2 receptor and the TRK receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
L'invention concerne un composé de formule Ia ou Ib sous forme libre, de sel ou de solvate, dans laquelle R1, R2, R3, R4, R5, R20, R24, R25, X, Y et Z ont les significations indiquées dans la description, ledit composé étant utile pour le traitement de maladies induites par le récepteur de ALK-5 et/ou ALK-4. Ces composés sont également utiles pour le traitement de maladies induites par le récepteur de Pi3k, le récepteur de JAK-2 et le récepteur de TRK. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés de préparation des composés.
Albaugh Pamela A.
Capraro Hans-Georg
Chopiuk Greg
Ferrand Sandrine
Furet Pascal
Fetherstonhaugh & Co.
Novartis Ag
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