C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4545 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 31/551 (2006.01) C07D 471/04 (2006.01) C07D 487/14 (2006.01)
Patent
CA 2696211
The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
L'invention concerne des composés hétérocycliques hexagonaux substitués de la formule structurelle I, qui sont des inhibiteurs de l'enzyme dipeptidylpeptidase-IV et qui sont utiles pour le traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidylpeptidase-IV est impliquée, comme l'obésité et le diabète, en particulier les diabètes de type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles l'enzyme dipeptidylpeptidase-IV est impliquée.
Biftu Tesfaye
Cox Jason M.
Feng Danqing
Qian Xiaoxia
Weber Ann E.
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
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