Heterocyclic compounds as inhibitors of c-fms kinase

Details Heterocyclic compounds as inhibitors of c-fms kinase Heterocyclic compounds as inhibitors of c-fms kinase

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61K 31/513 (2006.01) A61K 31/54 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2649736

The invention is directed to compounds of Formula (I) : wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. The compounds of formula (I) can be used in methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone.

L'invention concerne des composés de formule (I): où Z, X, J, R2 et W sont présentés dans la description, ainsi que des solvates, hydrates, tautomères et sels pharmaceutiquement acceptables de ceux-ci, qui inhibent des protéines tyrosine kinases, surtout une c-fms kinase. Les composés de formule (I) peuvent être utilisés dans des méthodes de traitement de maladies auto-immunes et de maladies à composant inflammatoire ; de traitement de métastases de cancer de l'ovaire, de cancer de l'utérus, de cancer du sein, de cancer de la prostate, de cancer du poumon, de cancer du côlon, de cancer de l'estomac, de leucémie à tricholeucocytes ; et de traitement de la douleur, y compris la douleur squelettique causée par des métastases tumorales ou l'arthrose, ou la douleur viscérale, inflammatoire et neurogénique ; ainsi que l'ostéoporose, la maladie de Paget et autres maladies dans lesquelles la résorption osseuse sert de médiateur de morbidité, y compris la polyarthrite rhumatoïde et d'autres formes d'arthrite inflammatoire, l'arthrose, les prothèses défectueuses, le sarcome ostéolytique, le myélome et les métastases tumorales osseuses.

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