C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 213/74 (2006.01) C07D 215/38 (2006.01) C07D 239/42 (2006.01) C07D 263/48 (2006.01) C07D 263/58 (2006.01) C07D 277/82 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2139442
A compound of formula (1): A1-X-(CH2)n-O-A2-A3-Y.R2 or a tautomeric form thereof and/or a pharmaceutically ac- ceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubsti- tuted aromatic heterocyclyl group; A2 represents a benzene ring having three optional substituents; A3 represents a moiety of formula -(CH2)m-CH(OR1)-wherein R1 represents substituted or unsubstituted alkyl, aryl, aralkyl or alkylcarbonyl and m represents an integer in the range of from 1 to 5, or A3 represents a moiety of formula -(CH2)m?1-CH = C(OR1)- wherein R1 and m are as defined above; R2 represents OR3 wherein R3 represents hydrogen, alkyl, aryl or aralkyl or R2 represents an aromatic heterocyclyl group or -NR4R5 wherein R4 and R5 each independently represent hydrogen, alkyl or alkylcarbonyl or R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclic ring, providing that R2 represents an aromatic heterocyclyl group only when Y as defined below represents a bond; X represents NR wherein R represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; Y represents CO or CS or a bond providing that Y represents a bond only when R2 represents the above-mentioned aromatic heterocyclyl group; and n represents an integer in the range of from 2 to 6; a process for preparing such a compound, a composition comprising such a compound and the use of such a compound and composition in medicine.
Haigh David
Sime John T.
Borden Ladner Gervais Llp
Smithkline Beecham P.l.c.
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