C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 167/234
C07D 277/04 (2006.01) A61K 31/425 (2006.01) A61K 31/54 (2006.01) C07D 277/06 (2006.01) C07D 279/06 (2006.01) C07D 417/02 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2020805
NOVEL HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN AND SULFUR, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME A b s t r a c t The invention relates to novel nitrogen- and sulfur- -containing heterocyclic compounds of the formula (I) acid addition salts thereof pharmaceutical compositions containing them and a process for their preparation. In the formula (I) (I), Image Ar stands for an optionally mono- or polysubstituted aryl or heteroaryl group; R1 means a carbonyl or (C2-6alkenyl)carbonyl group; R2 stands for hydrogen, C1-6alkyl phenyl or phenyl (C1-4alkyl) group; R3 means hydrogen or (C1-6alkoxy)carbonyl group; R4 and R5 stand independently from each other for hydrogen or C1-6alkyl group; R6 means hydrogen C1-6alkyl group or halophenyl group; m is 0 or 1; and n is 1 or 2, with the proviso that R2 means hydrogen when m is 0. The compounds of formula (I) show a significant cerebral antihypoxic action and thus, they can be used for the treatment of diseases caused by hypoxic brain damages such as a.g. the senile dementia, Alzheimer's disease or disturbances of the cognitive function.
Bodo Mihaly
Csomor Katalin
Gere Aniko
Groo Dora
Karpati Egon
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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