A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5375 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2527079
This invention relates to pyrimidine compounds of formula (I), formula (I')~ and formula (I~~): formula (I) and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, R5, U, V, W, X, Y, Z, and n are defined herein. This invention also relates to compositions comprising these compounds and methods for using them. The compounds and compositions of this invention are useful to treat or prevent disorders associated with excessive bone loss, including, without limitation periodontal disease, non-malignant bone disorders (such as osteoporosis, Paget's disease of bone, osteogenesis imperfecta, fibrous dysplasia, and primary hyperparathyroidism) estrogen deficiency, inflammatory bone loss, bone malignancy, arthritis, osteopetrosis, and certain cancer-related disorders (such as hypercalcernia of malignancy (HCM), osteolytic bone lesions of multiple myeloma and osteolytic bone metastases of breast cancer and other metastatic cancers).
L'invention porte sur des composés de pyrimidine représentés par la formule (I), (I')' et (I''), et sur des sels, des solvants, des clathrates et des promédicaments de ceux-ci pharmaceutiquement acceptables, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, U, V, W, X, Y, Z, et n étant définis ci-après. Cette invention concerne aussi des compositions contenant ces composés et des procédés d'utilisation. Les composés et les compositions de l'invention sont utiles dans le traitement et la prévention de troubles associés à la perte osseuse excessive, y compris, sans limitation, les parodontopathies, les maladies osseuses non malignes (telles l'ostéoporose, la maladie osseuse de Paget, l'ostéogenèse imparfaite, la dysplasie fibreuse, et l'hyperparathyroïdisme), la déficience en oestrogènes, la perte osseuse inflammatoire, la malignité osseuse, l'arthrite, l'ostéoporose, et certains troubles liés au cancer (tels que l'hypercalcémie de malignité (HCM), les lésions osseuses ostéolytiques de plusieurs myélomes et les métastases osseuses ostéolytiques du cancer du sein et d'autres cancers métastatiques).
Koya Keizo
Nagai Masazumi
Ono Mitsunori
Sun Lijun
Wada Yumiko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Synta Pharmaceuticals Corp.
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