Heterocyclic compounds having angiotensin ii antagonistic...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/10 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01) C07D 419/10 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2112050

Abstract of the disclosure This invention relates to a compound represented by the formula Image (I) wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R1 and R2, further substituents; R1 stands for an optionally substituted hydrocarbon residue which is optionally bonded through a hetero-atom; R2 stands for a group capable of liberating proton in a living body or a group convertible thereinto; R3 stands for an 5-7 membered optionally substituted heterocyclic residue having, as a group capable of constituting the ring, carbonyl group, thiocarbonyl group, an optionally oxidized sulfur atom or a group convertible into them; X shows that the ring Y and the ring W are bonded to each other directly or through a spacer having an atomic length of two or less; the ring W and the ring Y are each an optionally substituted aromatic hydrocarbon or aromatic heterocyclic residue; and n denotes an integer of 1 to 3, or a salt thereof and to an angiotensin II antagonistic agent containing the compound (I) or a salt thereof.

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