C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/60 (2006.01) A01N 35/10 (2006.01) A01N 43/00 (2006.01) A61K 31/16 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/695 (2006.01) C07C 233/31 (2006.01) C07C 255/64 (2006.01) C07C 323/47 (2006.01) C07D 209/16 (2006.01) C07D 209/20 (2006.01) C07D 307/81 (2006.01) C07D 333/58 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2129145
2129145 9318023 PCTABS00025 Compounds of formula (I), and salts and prodrugs thereof, wherein Q1 is halo substituted phenyl; naphthyl; indolyl; benzthiophenyl; benzofuranyl; benzyl; or fluorenyl; .... is an optional covalent bond; one of X and Y is H and the other is hydroxy or C1-6alkoxy, or X and Y are together =0 or =NOR5; R1 and R2 are H; C1-6alkyl optionally substituted by hydroxy, cyano, CORc, CO2Rc, CONRcRd, or NRcRd (where Rc and Rd are H, C1-6 alkyl or phenyl (C0-4alkyl) optionally substituted by C1-6alkyl, C1-6alkoxy, halo and trifluoromethyl); phenyl (C1-4alkyl) (optionally substituted by C1-6alkyl, C1-6alkoxy, halo or trifluoromethyl); CORc; CO2Rc; CONRcRd; COC1-6alkylNRcRd; CONRcCOORd; or SO2Rc; R3 is H, C1-6alkyl or C2-6alkenyl; and R4 is phenyl optionally substituted by C1-6alkyl, C2-6alkenyl, C2-6alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, ORa, SRa, SORa, NRaRb, NRaCORb, NRaCO2Rb, CO2Ra or CONRaRb, where Ra and Rb are H, C1-6alkyl, phenyl or trifluoromethyl; are tachykinin antagonists.
Lewis Richard T.
Macleod Angus M.
Merchant Kevin J.
Merck Sharp & Dohme Limited
Swabey Ogilvy Renault
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