Heterocyclic compounds, their production and use

Details Heterocyclic compounds, their production and use Heterocyclic compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2072541

Compound of the formula: (see above formula) (wherein R1 is optionally substituted hydrocarbon, R2 is optionally substituted 5- to 7-membered hetero- cyclic having C=O, C=S, S, SO or SO2 as a ring-forming group, X is a bond or a spacer, W and Y are optionally substituted hydrocarbon or heterocyclic residue, n is 1 or 2, a and b are one or two optionally substituted carbon or hetero atom, c is optionally substituted carbon or hetero atom) or a salt thereof shows a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

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