C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/24 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2128055
HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE ABSTRACT OF THE DISCLOSURE Novel compounds represented by the formula: Image wherein the ring A and the ring B each stand for an optionally substituted benzene ring; Ar stands for an optionally substituted aryl group or an optionally substituted heterocyclic group; Q stands for an oxygen atom or a sulfur atom; R stands for a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group; X stands for -O- or -NR1- wherein R1 stands for a hydrogen atom or an optionally substituted hydrocarbon group; Y stands for -O-, -NR2- wherein R2 stands for a hydrogen atom or an optionally substituted hydrocarbon group, or a bond; m denotes 1, 2 or 3, and n denotes 0, 1 or 2, and salts thereof which have an excellent calcium- or substance P receptor-antagonistic activity, being useful for treating a cerebralvascular disorder in mammals such as cerebralischemia, cerebral edema and neuronal damage, their production and use.
Ichimori Yuzo
Imamoto Tetsuji
Natsugari Hideaki
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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