Heterocyclic compounds useful as inhibitors of tyrosine kinases

Details Heterocyclic compounds useful as inhibitors of tyrosine kinases Heterocyclic compounds useful as inhibitors of tyrosine kinases

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4355 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 217/24 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 235/30 (2006.01) C07D 277/00 (2006.01) C07D 491/20 (2006.01) C07D 498/04 (2006.01) C07D 513/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2384378

Disclosed are novel compounds of formula (I) wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosina kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of formula (I).

Cette invention se rapporte à de nouveaux composés représentés par la formule (I), où Ar¿1?, R¿a?, R¿4?, R¿5?, X et Y sont définis dans les pièces descriptives de la demande, ces composés servant d'inhibiteurs de certaines protéine-tyrosine-kinases et étant par conséquent utiles dans le traitement des maladies associées à ces kinase, telles que des maladies résultant d'une prolifération cellulaire inappropriée, notamment les maladies auto-immunes, les maladies inflammatoires chroniques, les maladies allergiques, le rejet des greffes et le cancer. Cette invention concerne également des procédés de préparation de ces composés, de nouveaux intermédiaires utiles dans ces procédés et des compositions comprenant ces composés représentés par la formule (I).

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