C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/85 (2006.01) A61K 31/343 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07D 307/80 (2006.01) C07D 307/84 (2006.01)
Patent
CA 2533747
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
La présente invention concerne des procédés pour utiliser des composés représentés par la formule I, des compositions pharmaceutiques les contenant, et des procédés pour prévenir, gérer et traiter des troubles du métabolisme et des troubles modulés par l'inhibition de la MDC. Les composés de l'invention sont utiles pour prévenir, gérer, et traiter des maladies liées au passage métabolique des acides gras/du glucose régulé par malonyl-CoA. Ces composés et des compositions pharmaceutiques qui les contiennent, sont indiqué(e)s en particulier dans le cadre de la prévention, de la gestion et du traitement des maladies cardio-vasculaires, du diabète, du cancer et de l'obésité.
Cheng Jie Fei
Dyck Jason R.
Liu Xuewei
Lopaschuk Gary D.
Nguyen Bao Ngoc
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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