Heterocyclic compounds useful as nurr-1 activators

Details Heterocyclic compounds useful as nurr-1 activators Heterocyclic compounds useful as nurr-1 activators

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61P 25/16 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 413/02 (2006.01)

Patent

CA 2515847

The present invention relates to compounds of formula (I) : wherein R1 is hydroxy, C1-4 alkoxy ,amino, C1-4 alkyl-amino, di C1-4alkylamino , benzyloxy or C2-C7 alkanoyl, R2 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy C1-4alkoxy, CF3, halogen, C1-4alkylamino, di C1-4alkylamino, di C1-4 alkylamino C1-4 alkoxy or N-C1-4 alkoxy C1-4 alkyl-N~-C1-4 alkylamino, N-C1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C1-4 alkoxy, wherein the C1-4 alkyl radicals in R2 are optionally further substituted by C1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3, X is O, Y is CH, Z is N and W is CH, (b) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3 or chloro, X is N, Y is O, Z is CH and W is CH, (c) R1 is not hydroxy when R2 is CF3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.

La présente invention concerne des composés de formule (I) dans laquelle: R¿1? est hydroxy, C¿1-4 ?alcoxy, amino, C¿1-4? alkyl-amino, di C¿1-4 ?alkylamino, benzyloxy ou C¿2-?C¿7? alcanoyle; R¿2? est C¿1-4?alkyle, C¿1-4 ?alcoxy, C¿1-4? alcoxy C¿1-4 ?alcoxy, CF¿3?, halogène, C¿1-4 ?alkylamino, di C¿1-4 ?alkylamino, di C¿1-4 ?alkylamino C¿1-4 ?alcoxy ou N-C¿1-4? alcoxy, C¿1-4? alkyl-N-C¿1-4? alkylamino, N-C¿1-4? alkyl-pipérazinyle, morpholinyle ou pyrrolidinyl-C¿1-4? alcoxy, les radicaux C¿1-4? alkyle de R¿2? étant éventuellement substitués par C¿1-4? alkyle, halogène, cyano, amino, alcoxy ou alkylthio; X est N ou O; Y est N, O ou CH; Z est N ou CH; et W est N ou CH, à la condition que (a) R¿1? n'est pas hydroxy ou C¿1-4? alcoxy lorsque R¿2? est CF¿3?, X est O, Y est CH, Z est N et W est CH, (b) R¿1? n'est pas hydroxy ou C¿1-4? alcoxy lorsque R¿2? est CF¿3? ou chloro, X est N, Y est O, Z est CH et W est CH, (c) n'est pas hydroxy lorsque R¿2? est CF¿3?, X est O, Y est N, Z est CH et W est CH, et (d) X et Y ne représentent pas O simultanément. L'invention a également pour objet des sels de ces composés, leur préparation, leur utilisation et des compositions pharmaceutiques qui les contiennent.

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