C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2481926
Disclosed are compounds which bind .alpha.4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by .alpha.4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
La présente invention a trait à des composés qui se lient aux intégrines .alpha.¿4?, de préférence le VLA-4. Certains de ces composés sont également inhibiteurs de l'adhésion leucocytaire et, notamment, l'adhésion leucocytaire provoquée par les intégrines .alpha.¿4?, de préférence le VLA-4. De tels composés sont utiles dans le traitement de maladies inflammatoires chez un patient mammalien, par exemple, un sujet humain, telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence associée au sida, le diabète, la maladie intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation tissulaire, la métastase tumorale et l'ischémie myocardique. Les composés peuvent être administrés pour le traitement de maladies cérébrales inflammatoires telles que la sclérose en plaques.
Konradi Andrei W.
Pleiss Michael A.
Semko Christopher M.
Smith Jenifer
Stappenbeck Frank
Elan Pharmaceuticals Inc.
Ridout & Maybee Llp
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