Heterocyclic cytotoxic agents

Details Heterocyclic cytotoxic agents Heterocyclic cytotoxic agents

C - Chemistry, Metallurgy

07

D

C07D 215/26 (2006.01) A61K 31/47 (2006.01) C07D 221/18 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2313797

The invention provides compounds of formula (I) wherein R1-R8 and X and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating cancer using compounds of formula (I).

L'invention concerne des composés de formule (I): dans laquelle R¿1?-R¿8? et X et Y ont l'une des significations spécifiées dans le descriptif, ainsi que leurs sels pharmaceutiquement acceptables. L'invention concerne également des compositions pharmaceutiques renfermant un composé de formule (I), des procédés de préparation des composés de formule (I), des produits intermédiaires utiles pour la préparation de composés de formule (I), ainsi que des procédés thérapeutiques de traitement du cancer à l'aide des composés de formule (I).

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