Heterocyclic derivative and use thereof

Details Heterocyclic derivative and use thereof Heterocyclic derivative and use thereof

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 277/30 (2006.01)

Patent

CA 2720343

The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like. An sGC activation drug containing a compound represented by the formula (II): (see formula II) wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.

L'invention concerne un activateur de sGC, notamment un composé qui est utile pour la prévention ou le traitement de maladies incluant l'hypertension, les maladies cardiaques ischémiques, l'insuffisance cardiaque, les maladies rénales, les maladies artériosclérotiques, la fibrillation auriculaire, l'hypertension pulmonaire, le diabète, les complications du diabète, le syndrome métabolique, la maladie artérielle périphérique et le dysfonctionnement érectile, et qui présente d'excellentes activités pharmacologiques, d'excellentes propriétés physico-chimiques et autres. L'invention concerne spécifiquement un activateur de sGC qui comprend un composé représenté par la formule générale (II) [dans laquelle chaque symbole est tel que défini dans la description] ou un de ses sels en tant qu'ingrédient actif.

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